Motif ID: SOX{8,9,10}.p2

Z-value: 1.883


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9



Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_20005704 2.635 NAV2
neuron navigator 2
chr10_-_123346148 2.205 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr7_-_11838260 1.892 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr7_-_27171673 1.878 NM_152739
HOXA9
homeobox A9
chr12_-_6103945 1.781 NM_000552
VWF
von Willebrand factor
chr7_-_27171600 1.754 HOXA9
homeobox A9
chr3_-_150422474 1.681 NM_000096
CP
ceruloplasmin (ferroxidase)
chr6_+_148705421 1.639 NM_015278
SASH1
SAM and SH3 domain containing 1
chr7_-_27171648 1.591 HOXA9
homeobox A9
chr11_+_101488380 1.579 NM_001195045
YAP1
Yes-associated protein 1
chr12_-_8706533 1.574 MFAP5
microfibrillar associated protein 5
chr17_-_76985538 1.481


chr1_+_200449905 1.434 NM_001017404
LGR6
leucine-rich repeat containing G protein-coupled receptor 6
chr12_-_8706637 1.342 NM_003480
MFAP5
microfibrillar associated protein 5
chr4_-_186969041 1.334 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_+_74491272 1.285 ALB
albumin
chr10_+_71482362 1.279 NM_018649
H2AFY2
H2A histone family, member Y2
chr13_+_112704077 1.253 MCF2L
MCF.2 cell line derived transforming sequence-like
chr10_+_71482542 1.238 H2AFY2
H2A histone family, member Y2
chr3_-_189354510 1.164 LOC339929
hypothetical LOC339929
chr2_-_56266408 1.125 LOC100129434
hypothetical LOC100129434
chr16_+_22432344 1.106 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr1_+_15957832 1.099 NM_017556
FBLIM1
filamin binding LIM protein 1
chr3_-_150993299 1.077 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr7_-_27206249 1.074 NM_000522
HOXA13
homeobox A13
chr10_+_104525877 1.051 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr4_-_186969202 1.041 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr2_+_223244606 1.036 NM_058165
MOGAT1
monoacylglycerol O-acyltransferase 1
chr6_-_128883125 1.027 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr7_+_72883128 1.021 NM_001305
CLDN4
claudin 4
chr3_+_190990142 1.017 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr8_-_22044463 1.016 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr20_+_60918836 1.012 NM_001853
COL9A3
collagen, type IX, alpha 3
chr10_+_24538094 1.009 KIAA1217
KIAA1217
chr7_+_134114957 1.008 CALD1
caldesmon 1
chr11_-_128567302 1.004 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr1_+_26376560 1.000 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr7_+_134114912 0.996 CALD1
caldesmon 1
chr6_-_42218692 0.994 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr8_-_38444398 0.991 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr2_-_164300758 0.989 NM_018086
FIGN
fidgetin
chr14_+_23008723 0.984 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr12_-_57600564 0.969 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_-_151848039 0.962 S100A16
S100 calcium binding protein A16
chr17_-_36996611 0.953 NM_000526
KRT14
keratin 14
chr12_-_51173238 0.951 NM_005554
KRT6A
keratin 6A
chr10_+_24795465 0.949 KIAA1217
KIAA1217
chr19_-_56582997 0.926 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr10_+_24795446 0.925 KIAA1217
KIAA1217
chr10_-_105835525 0.924 COL17A1
collagen, type XVII, alpha 1
chr10_-_105835609 0.910 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr1_+_144439069 0.908 NM_002614
PDZK1
PDZ domain containing 1
chr2_+_228386800 0.903 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr4_-_7991992 0.896 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr1_-_197173159 0.893 LOC100131234
familial acute myelogenous leukemia related factor
chr7_+_121300394 0.889 NM_002851
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr6_+_43565192 0.888 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr20_-_3097070 0.883 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr3_+_189354167 0.879 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr14_+_23008742 0.875 NGDN
neuroguidin, EIF4E binding protein
chr15_-_70277163 0.869 NM_001012642
GRAMD2
GRAM domain containing 2
chr10_+_24537725 0.849 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr8_+_40130143 0.845 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr17_-_1359745 0.843 INPP5K
inositol polyphosphate-5-phosphatase K
chr16_-_52877829 0.839 IRX3
iroquois homeobox 3
chr5_-_50714836 0.835 LOC642366
hypothetical LOC642366
chr7_-_27186400 0.830 NM_153715
HOXA10
homeobox A10
chr1_-_95165037 0.827 CNN3
calponin 3, acidic
chr5_+_50714996 0.813 ISL1
ISL LIM homeobox 1
chrX_+_15428820 0.807 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr5_-_92942680 0.800 FLJ42709
hypothetical LOC441094
chr5_-_134899537 0.799 NM_006161
NEUROG1
neurogenin 1
chr2_-_96769502 0.793 LMAN2L
lectin, mannose-binding 2-like
chr17_+_72795567 0.779 NM_001113492
SEPT9
septin 9
chr2_-_238164042 0.778 RAB17
RAB17, member RAS oncogene family
chr1_+_64012154 0.767 NM_001083592
NM_005012
ROR1

receptor tyrosine kinase-like orphan receptor 1

chr9_+_4782974 0.767 RCL1
RNA terminal phosphate cyclase-like 1
chr4_-_185963859 0.766 ACSL1
acyl-CoA synthetase long-chain family member 1
chr9_+_27099138 0.761 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr3_+_182900081 0.757 SOX2OT
SOX2 overlapping transcript (non-protein coding)
chr5_-_16989371 0.757 NM_012334
MYO10
myosin X
chr1_+_183970093 0.754 NM_031935
HMCN1
hemicentin 1
chr2_-_96769526 0.754 NM_001142292
NM_030805
LMAN2L

lectin, mannose-binding 2-like

chr14_+_36196523 0.753 NM_006194
PAX9
paired box 9
chr5_-_176769094 0.752 F12
coagulation factor XII (Hageman factor)
chr1_+_162795538 0.745 PBX1
pre-B-cell leukemia homeobox 1
chr6_-_2785682 0.744 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr20_-_17610828 0.743 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr16_-_21344158 0.741 NM_130464
NPIPL3
nuclear pore complex interacting protein-like 3
chr7_+_96473225 0.737 NM_005222
DLX6
distal-less homeobox 6
chr2_-_75650355 0.734 NM_032181
FAM176A
family with sequence similarity 176, member A
chr20_-_39680405 0.732 NM_032221
CHD6
chromodomain helicase DNA binding protein 6
chr5_-_16989290 0.726 MYO10
myosin X
chr1_+_226404037 0.726 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr1_+_34997928 0.723 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr6_+_17390910 0.723 NM_153020
RBM24
RNA binding motif protein 24
chr6_+_17390273 0.715 NM_001143941
RBM24
RNA binding motif protein 24
chr3_-_121883647 0.713 HGD
homogentisate 1,2-dioxygenase
chr1_-_16411690 0.712 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr8_+_70541631 0.710 SULF1
sulfatase 1
chr16_-_52877868 0.710 NM_024336
IRX3
iroquois homeobox 3
chr4_+_146623405 0.707 NM_001003688
SMAD1
SMAD family member 1
chr16_+_464844 0.706 NM_001142272
RAB11FIP3
RAB11 family interacting protein 3 (class II)
chr14_-_94306104 0.703 NM_173849
GSC
goosecoid homeobox
chr14_+_62740878 0.698 NM_020663
RHOJ
ras homolog gene family, member J
chrX_-_24600661 0.697 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr14_+_22375753 0.693 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr1_+_32512298 0.692 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr3_+_113200696 0.691 NM_001008273
TAGLN3
transgelin 3
chr1_+_207668787 0.686 NM_001104548
LOC642587
NPC-A-5
chr8_+_55533047 0.683 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr2_+_220200530 0.682 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr2_+_54536780 0.681 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_-_85703198 0.681 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_+_42701460 0.681 CCDC30
coiled-coil domain containing 30
chr15_+_96304911 0.678 NM_183376
ARRDC4
arrestin domain containing 4
chr20_-_49818268 0.675 ATP9A
ATPase, class II, type 9A
chr14_+_85066265 0.672 FLRT2
fibronectin leucine rich transmembrane protein 2
chr20_-_49818306 0.672 NM_006045
ATP9A
ATPase, class II, type 9A
chr15_+_96304942 0.668 ARRDC4
arrestin domain containing 4
chr1_+_47261826 0.668 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr2_+_37425240 0.664 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr11_-_116213511 0.660 NM_000039
APOA1
apolipoprotein A-I
chrX_+_105823723 0.659 NM_024539
RNF128
ring finger protein 128
chr4_-_159312973 0.658 FAM198B
family with sequence similarity 198, member B
chr1_+_26376611 0.655 CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr1_-_108032645 0.654 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr17_+_42283946 0.652 NM_003396
WNT9B
wingless-type MMTV integration site family, member 9B
chr9_-_72673753 0.649 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr9_-_74757735 0.649 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr12_-_129212720 0.648 FLJ31485
hypothetical LOC440119
chr1_-_6468108 0.645 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr6_+_114285209 0.645 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr12_-_8706746 0.641 MFAP5
microfibrillar associated protein 5
chr14_-_91483325 0.641 FBLN5
fibulin 5
chr5_+_57914658 0.640 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr4_-_159313167 0.637 NM_016613
FAM198B
family with sequence similarity 198, member B
chr4_+_185064799 0.636 STOX2
storkhead box 2
chr2_-_134042500 0.636 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr12_-_24606616 0.635 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr4_+_185064876 0.633


chr5_+_140583098 0.631 NM_018934
PCDHB14
protocadherin beta 14
chrX_+_85290106 0.628 NM_001139514
NM_053281
DACH2

dachshund homolog 2 (Drosophila)

chr12_+_62524778 0.626 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr5_+_178919298 0.623 NM_001040451
NM_001040452
RUFY1

RUN and FYVE domain containing 1

chr20_+_31613800 0.621 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr14_+_85066207 0.612 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr6_-_138862271 0.611 NM_001144060
NHSL1
NHS-like 1
chr8_+_70541412 0.610 NM_001128204
NM_015170
SULF1

sulfatase 1

chr2_-_88208650 0.610 NM_001443
FABP1
fatty acid binding protein 1, liver
chr14_-_22974707 0.610 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chrX_+_85290117 0.605 DACH2
dachshund homolog 2 (Drosophila)
chr12_-_57600336 0.604 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr12_-_87498225 0.601 NM_000899
NM_003994
KITLG

KIT ligand

chr3_-_150578023 0.601 TM4SF1
transmembrane 4 L six family member 1
chr14_+_22375747 0.599 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr8_-_38444675 0.597 FGFR1
fibroblast growth factor receptor 1
chr2_-_128138435 0.596 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr1_-_24311212 0.594 NM_152372
MYOM3
myomesin family, member 3
chr10_-_91451102 0.591 NBAS
neuroblastoma amplified sequence
chr17_-_71017509 0.591 NM_001142643
CASKIN2
CASK interacting protein 2
chr5_+_149960820 0.591 NM_001166208
SYNPO
synaptopodin
chr1_-_152431175 0.591 NM_152263
TPM3
tropomyosin 3
chr4_-_159313613 0.590 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr4_+_95898098 0.589 NM_001203
BMPR1B
bone morphogenetic protein receptor, type IB
chr9_-_35101534 0.586 KIAA1539
KIAA1539
chr9_-_35101592 0.580 KIAA1539
KIAA1539
chr20_-_17459973 0.580 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr20_-_38751289 0.579 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr14_-_64479198 0.578 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chrX_+_70359780 0.577 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr6_+_64289585 0.570 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr3_-_150533948 0.566 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr19_-_17236522 0.566 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr2_-_162639297 0.566 NM_001935
DPP4
dipeptidyl-peptidase 4
chr13_+_51927615 0.560 CKAP2
cytoskeleton associated protein 2
chr3_-_12561962 0.554 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr2_+_236068029 0.553 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr3_+_113200275 0.553 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr4_+_87070449 0.552 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr5_+_50714714 0.549 NM_002202
ISL1
ISL LIM homeobox 1
chr6_+_126282078 0.548 NCOA7
nuclear receptor coactivator 7
chr3_+_115099007 0.544 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr6_-_138862273 0.539


chr3_-_95230143 0.529 NM_001001850
STX19
syntaxin 19
chr6_-_28663045 0.529 NM_052923
SCAND3
SCAN domain containing 3
chr5_-_176769141 0.527 NM_000505
F12
coagulation factor XII (Hageman factor)
chr17_-_36938025 0.526 KRT19
keratin 19
chr2_-_45090025 0.526 NM_016932
SIX2
SIX homeobox 2
chr20_-_17610704 0.519 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr14_-_37795290 0.518 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr17_-_36938111 0.517 NM_002276
KRT19
keratin 19
chr12_-_97812633 0.516 ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr14_-_30565275 0.515 NM_001083893
NM_014574
STRN3

striatin, calmodulin binding protein 3

chr14_+_34661497 0.513 NM_014672
KIAA0391
KIAA0391
chr14_-_93859394 0.513 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr2_+_190248955 0.512 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chr1_+_176577228 0.510 NM_004841
RASAL2
RAS protein activator like 2
chr3_-_172227223 0.506 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr5_+_76418214 0.506 LOC728723
hypothetical LOC728723

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.36 8.77e-09 GO:0007275 multicellular organismal development
1.34 1.26e-08 GO:0032502 developmental process
1.38 1.39e-08 GO:0048856 anatomical structure development
1.40 3.71e-08 GO:0048731 system development
1.54 1.27e-06 GO:0007399 nervous system development
1.23 9.12e-06 GO:0032501 multicellular organismal process
1.48 4.29e-05 GO:0009653 anatomical structure morphogenesis
1.16 5.65e-05 GO:0050789 regulation of biological process
1.15 8.01e-05 GO:0065007 biological regulation
1.17 9.33e-05 GO:0050794 regulation of cellular process
1.28 1.39e-04 GO:0016043 cellular component organization
1.38 1.67e-04 GO:0048869 cellular developmental process
1.61 2.76e-04 GO:0048699 generation of neurons
1.37 2.86e-04 GO:0030154 cell differentiation
1.10 2.91e-04 GO:0009987 cellular process
1.26 6.52e-04 GO:0071840 cellular component organization or biogenesis
1.57 7.08e-04 GO:0022008 neurogenesis
2.93 1.02e-03 GO:0006334 nucleosome assembly
1.52 1.09e-03 GO:0022607 cellular component assembly
1.64 1.95e-03 GO:0030182 neuron differentiation
2.78 3.10e-03 GO:0031497 chromatin assembly
1.29 4.59e-03 GO:0071842 cellular component organization at cellular level
1.91 4.68e-03 GO:0007411 axon guidance
1.56 5.21e-03 GO:0051128 regulation of cellular component organization
1.80 5.55e-03 GO:0007409 axonogenesis
2.65 5.61e-03 GO:0065004 protein-DNA complex assembly
1.64 6.21e-03 GO:0032989 cellular component morphogenesis
1.72 6.21e-03 GO:0048858 cell projection morphogenesis
1.57 7.84e-03 GO:0071844 cellular component assembly at cellular level
2.46 8.14e-03 GO:0006323 DNA packaging
2.65 8.59e-03 GO:0034728 nucleosome organization
1.71 8.64e-03 GO:0032990 cell part morphogenesis
1.74 9.19e-03 GO:0048646 anatomical structure formation involved in morphogenesis
2.51 1.72e-02 GO:0071824 protein-DNA complex subunit organization
1.73 1.78e-02 GO:0048812 neuron projection morphogenesis
1.74 1.92e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.32 2.12e-02 GO:0048513 organ development
1.61 2.52e-02 GO:0000902 cell morphogenesis
1.26 2.56e-02 GO:0071841 cellular component organization or biogenesis at cellular level
2.25 2.77e-02 GO:0071103 DNA conformation change
1.48 2.96e-02 GO:0050793 regulation of developmental process
1.76 3.03e-02 GO:0007264 small GTPase mediated signal transduction
1.67 3.12e-02 GO:0000904 cell morphogenesis involved in differentiation
1.53 3.29e-02 GO:2000026 regulation of multicellular organismal development
1.41 3.33e-02 GO:0044085 cellular component biogenesis
2.30 3.48e-02 GO:0006333 chromatin assembly or disassembly
1.58 3.93e-02 GO:0045893 positive regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.66 4.84e-04 GO:0030054 cell junction
1.08 6.23e-04 GO:0005622 intracellular
3.22 1.32e-03 GO:0000786 nucleosome
1.16 3.18e-03 GO:0005634 nucleus
1.08 4.24e-03 GO:0044424 intracellular part
1.74 6.66e-03 GO:0031012 extracellular matrix
1.94 8.49e-03 GO:0000785 chromatin
2.02 9.20e-03 GO:0005911 cell-cell junction
2.49 1.46e-02 GO:0032993 protein-DNA complex
2.04 3.61e-02 GO:0070161 anchoring junction
1.72 4.76e-02 GO:0005578 proteinaceous extracellular matrix
1.30 4.81e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.08 7.92e-04 GO:0005488 binding
1.14 1.76e-03 GO:0005515 protein binding
1.44 1.08e-02 GO:0001071 nucleic acid binding transcription factor activity
1.44 1.08e-02 GO:0003700 sequence-specific DNA binding transcription factor activity